2024 TT HealthWatch Archive

TT HealthWatch - Friday, June 28, 2024

This week's topics include six biotypes for anxiety and depression, overuse of aspirin for primary prevention, managing gestational diabetes, and medicines and acute liver injury.

0:33 Overuse of aspirin for primary prevention
1:32 Discouraged use in those over 75
2:32 Our listeners need to talk with their doctor
2:52 Gestational diabetes management
3:52 Increased C-sections, macrosomia
4:52 Start in pre-pregnancy period
5:52 Eight- to 10-fold risk
6:54 Acute liver injury and medications
7:54 Seventeen medications associated
8:54 Six biotypes in depression and anxiety
9:54 Task and no-task brain scans
10:52 Large number of things contribute
11:52 MRI before and after treatment
12:41 End

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TT HealthWatch - Friday, June 21, 2024

This week's topics include expanding the window for treating ischemic stroke, new agents for treating ischemic stroke, managing obesity in children and adolescents, and preventing surgical site infections.

0:36 Expanding the window for treating ischemic stroke
1:33 Complete recovery 10% more
2:33 Routine CT scanning
2:44 Comparing two agents to treat ischemic stroke
3:44 More in the reteplase group had hemorrhage
4:45 Dosing based on heart attack experience
5:24 Preventing surgical site infections
6:24 Up to a year after cardiac surgery
7:24 May look for staph
7:44 Interventions for high BMI in children and adolescents
8:46 Give a B recommendation to behavioral interventions
9:45 Don't address bariatric surgery
10:45 Policy changes needed
11:45 Increased risk of early death
12:12 End

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TT HealthWatch - Friday, June 14, 2024

This week's topics include eye training to prevent myopia worsening, nurse intervention to manage blood pressure post-stroke, preoxygenation before intubation, and risk of a second cancer after CAR-T.

0:40 Cancers subsequent to CAR-T therapy
1:40 Only one person with a T cell cancer
2:40 Must do large populations to identify risk
3:15 Preoxygenation before intubation
4:15 More hypoxemia in oxygen mask group
5:15 Takes a little more time
6:09 Can nurses control blood pressure post stroke in Black and Hispanic patients
7:10 450 participants who'd had a stroke
8:10 Nurses talked about lifestyle in addition to blood pressure
8:50 Training eyes to slow down myopia in kids
9:50 Occurring globally
10:50 Myopia is nearsightedness
11:50 Employ computers to treat
12:31 End

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TT HealthWatch - Friday, June 7, 2024

This week's topics include stepped palliative care, active surveillance for prostate cancer, artery inflammation as a predictor of cardiovascular events, and diets and medicine in IBS.

0:44 Inflammation in arteries and cardiovascular events
1:41 Over 40,000 patients
2:45 More inflamed arteries, the more the risk
3:00 IBS, diet and medication
4:00 Three arms: two diets and optimized medication
5:03 Diets both better than medication
6:04 Wheat-free and gluten-free
7:00 Long-term outcomes in prostate cancer with active surveillance
8:04 Ten-year incidence of metastasis
9:11 Stepped palliative care for patients with lung cancer
10:12 Those with a ten point or greater decline
11:12 Over 24 weeks
12:18 End

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TT HealthWatch - Friday, May 31, 2024

This week's topics include fluoride in pregnancy and outcomes in children, contagion of mental illness, statins in old and very old people, and hypertension after kidney donation.

0:48 Statins in old and very old
1:48 Increased risk for muscle pain or liver disease
2:48 Started on a statin
3:20 Maternal fluoride levels and neurobehavior in children
4:22 Increase in biomarker results in increased issues in kids
5:20 Parents score behavioral issues
6:16 Hypertension after kidney donation
7:18 Does hyperfiltration compromise?
8:19 Liver attempts to regenerate
9:10 Are mental health issues transmissible?
10:10 713,000+ in cohort
11:10 These issues cluster
12:10 Normalization of mental disorders
13:17 End

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TT HealthWatch - Friday, May 24, 2024

This week's topics include early diagnosis and treatment of COPD and asthma, use of GLP-1 agonists in adolescents and young adults, implications of new lung function equations, and benefits of cancer drug trials.

0:40 Implications of race adjustment in lung function equations
1:40 Over 12 million reclassified for lung function
2:40 Can be other confounders
3:40 Would differentiate race
4:40 There are race-based conditions
5:00 Survival benefit with cancer clinical trials
6:00 Quality of the trials
7:00 Routinely apply guidelines
7:30 Dispensing GLP-1 agonists to young
8:30 Three approved for Type 2 diabetes in adolescents
9:30 600% increase in use
10:05 Early diagnosis of COPD and asthma
11:05 Refer to pulmonologist
12:33 End

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TT HealthWatch - Friday, May 17, 2024

This week's topics include a new agent for high triglycerides, the impact of low testosterone on mortality in men, ultra-processed foods and mortality, and cardiovascular risk assessment improvement.

0:40 Improving assessment of cardiovascular risk
1:40 Trip through electronic medical record
2:40 Some cost and side effects
3:00 Association of ultra-processed foods with mortality
4:00 4% higher all-cause mortality
5:00 Surprised that cancer and CVD mortality not increased
6:00 Evidence in other studies for demyelination
6:36 New treatment for high triglycerides
7:40 Injected medication
8:40 Doesn't lower cholesterol
9:00 Low testosterone in men and mortality
10:00 Low testosterone increased mortality
11:04 Less binding globulin?
12:55 End

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TT HealthWatch - Friday, May 10, 2024

This week's topics include mortality among U.S. youth, updated breast screening guidelines, treating large strokes, and sickle cell treatment.

0:34 Sickle cell treatment
1:34 Take out progenitor cells
2:34 Side effects of treatment and cost
3:32 Significantly decreases survival
3:43 Racial and ethnic differences in mortality in U.S. youth
4:45 About twice as high among other ethnicities
5:48 Black youth eight times more likely to die of asthma
6:40 Treatment of very large strokes
7:40 333 patients within six hours
8:45 Practice changing
9:00 Breast cancer screening guidelines update
10:00 Older women and additional screening not known
11:00 Don't apply to some women
12:05 End

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TT HealthWatch - Friday, May 3, 2024

This week's topics include Medicare negotiation on drugs and a loophole, neomycin for preventing respiratory viral infections, diagnostic error in mental health conditions, and use of two diabetes medications together and subsequent chronic disease risk.

0:45 Two of the newer medicines for diabetes taken together
1:40 Over 15,000 people
2:40 Seem to have so many global impacts
3:05 Medicare drug price negotiation loophole
4:05 Very impressive results
5:05 Federal appeals court ruling
6:05 Exempts from negotiations
6:23 Diagnostic error in mental health
7:23 Mistake a physical illness
8:25 Neomycin intranasally
9:25 Sars-CoV2 and influenza A
10:25 Reduced infection and transmission
11:20 Widely available and generic
12:24 End

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TT HealthWatch - Friday, April 26, 2024

This week's topics include autism rates among males and females, consequences of atrial fibrillation, antipsychotics among those with dementia, and antibiotic use utilizing AI.

0:41 Atrial fibrillation and its complications
1:41 Increased risk factors
2:41 Treat with medication or ablation
3:30 Autism heritability in males and females
4:30 No support for environmental shared factors
5:33 Tried to account for with modeling
6:23 Antibiotics, AI and common infections
7:23 Fifty different variables
8:23 Patient specific factors
9:10 Antipsychotics and dementia
10:10 New antipsychotic use increased risk of pneumonia
11:10 Care providers
12:42 End

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TT HealthWatch - Friday, April 19, 2024

This week's topics include a new drug for early Parkinson's, Paxloivd and Covid, pragmatic model for chronic kidney disease, and lymph node removal and breast cancer.

0:45 Breast cancer and lymph node removal
1:47 Usual care survival 90%
2:45 One percent over five years
3:00 Rate of hospitalization in chronic kidney disease
4:00 Outcomes the same
5:01 Usual care pretty good
6:01 Engage physicians and patients early
6:20 Paxolvid indications
7:20 Twelve or thirteen days to resolution
8:23 Early Parkinson's medicine
9:23 12 months of treatment
10:23 Should enroll more?
11:57 End

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TT HealthWatch - Friday, April 12, 2024

This week's topics include decolonizing patients and infections in the hospital, delirium and dementia, brain size over the last few decades, and are biosimilars cheaper for patients.

0:35 Brain size over the last few decades
1:35 About a 7% greater volume
2:35 Bigger brains start in early childhood
3:55 Biosimilar costs
4:53 Cost about 10% higher
5:45 Does delirium predict dementia?
6:46 Recurrent delirium with dose response
7:47 Programs to reduce delirium in older patients
8:51 Multidrug resistant organisms, iodine and chlorhexidine
9:52 Decolonize every five days
11:04 Don't need surveillance
12:27 End

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TT HealthWatch - Friday, April 5, 2024

This week's topics include deep learning to help predict cardiovascular events molnupiravir in, immunocompromised people with COVID-19, sleep and exercise, and oral steroids in preschool wheeze.

0:42 Molnupiravir, COVID-19 and immunocompromised people
1:42 Samples up to 44 days post-treatment
2:42 Causes mutagenesis
3:44 Ongoing surveillance?
4:14 Oral steroids in preschool wheeze
5:21 Greater reduction in wheezing severity score
6:21 How often it recurs?
6:33 Use of machine learning to estimate CVD risk with radiographs
7:35 Compared with 2000+ with known risk
8:35 Routine chest X-ray informs risk
9:35 Exercise and sleep quality
10:35 Physically active at beginning and 10 years later
12:12 End

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TT HealthWatch - Friday, March 29, 2024

This week's topics include differences in donor heart acceptance by race and gender, medication for self-managed abortion, aspirin and MASLD, and diagnosing Parkinson's with a skin biopsy.

0:40 Aspirin for fatty liver disease
1:40 Low dose aspirin for six months
2:40 Primary prevention?
3:03 Donor heart acceptance
4:03 Just shy of 14,000 donors
5:03 More likely to have antibodies
5:45 Diagnosing Parkinson's with skin biopsy
6:45 Could detect in between 92-100%
7:45 Diagnosis of Lewey body dementia
8:45 Medication abortion before and after Dobbs
9:46 Provisions increased
10:46 Sued the FDA
12:12 End

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TT HealthWatch - Friday, March 22, 2024

This week's topics include advances in treating early breast cancer, stroke after COVID-19 vaccination, anti-seizure meds during pregnancy and ASD, and oxygen targets in critically ill people.

0:38 Stroke after bivalent COVID-19 vaccine
1:35 No increased risk with this vaccine alone
2:32 Public messaging
2:41 Personalized oxygen settings for patients in the ICU
3:41 Lower level resulted in more days alive without life support
4:41 Lowering blood glucose?
5:42 Verify in randomized trials
6:43 Risk of autism in kids in moms on anti-seizure meds during pregnancy
7:43 Increased risk whether on medicine or not
8:46 Treatment of early breast cancer
9:46 CDK4/6 inhibitor
10:46 No significant side effects
11:37 Younger than median age at diagnosis
12:16 End

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TT HealthWatch - Friday, March 15, 2024

This week's topics include new screening methods for colorectal cancer, a drug coated balloon for blocked stents in the heart, delta 8 THC use, and mortality and treated ADHD.

0:39 How to treat blocked stents
1:40 Over a year does reblockage occur?
2:40 Bypass may be more durable in some
3:00 Treating ADHD with medicines and mortality
4:00 Mean age at diagnosis 17.4 years
5:00 Still questions remain
6:00 6% of youths worldwide
6:25 THC and marijuana use in youths in the US
7:25 About 11% use over preceding year
8:25 Similar to tianeptine and kratom?
9:10 Screening for colorectal cancer
10:10 Genomic alterations detection
11:10 Stool sample collected
12:06 End

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TT HealthWatch - Friday, March 8, 2024

This week's topics include microplastics in arteries, deaths due to alcohol use, obesity and its consequences, and steps for the sedentary.

0:31 Microplastics and arteries
1:31 Looked at plaque in 304 patients
2:31 May have to do with baseline risk factors
3:31 More questions than answers
3:42 Worldwide obesity and risk of developing Type 2 diabetes
4:42 Obesity accelerating worldwide
5:42 Identify and stop the process
6:42 Underweight birthweight and overweight at 20
7:44 Steps in the sedentary
8:44 Total daily steps and sedentary lifestyle
9:45 About three miles
10:07 Deaths due to alcohol use
11:08 58 alcohol-related conditions
12:08 Dramatic increase over a short period of time
13:18 End

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TT HealthWatch - Friday, March 1, 2024

This week's topics include Medicaid expansion and healthcare workers, brain impact of long Covid, a drug for severe food allergies, and cardiac rehabilitation.

0:41 Cognition and memory after Covid
1:41 More severe disease leads to greater deficits
2:41 Severity related to strain of virus
3:26 Cardiac rehabilitation
4:26 The earlier the better
5:26 Automatic referral and navigator
6:30 Medicaid expansion and healthcare workers
7:30 Lower income workers on Medicaid
8:31 Bigger safety net
9:31 Trickle down is not a good strategy
10:00 Antibody to IgE
11:00 Children and adolescents with food allergy
12:00 Study participants admired
12:41 End

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TT HealthWatch - Friday, February 23, 2024

This week's topics include a longitudinal study of Alzheimer’s markers, CAR-T cells for autoimmunity, methods of illegal opioid overdose, and safety and efficacy of telemedicine abortion.

0:35 Method of use in drug overdose deaths in 2022
1:35 Smoking most common
2:30 Smoking, snorting, injection and ingestion
3:20 Effectiveness and safety of telemedicine abortion
4:20 99.8% NOT followed by an adverse event
5:20 Multiple groups benefit
6:20 Women who experience unintended pregnancy
7:00 New therapy for autoimmune diseases
8:00 How expensive are they?
8:36 Biomarkers previous to Alzheimer's
9:36 Tau and total tau
10:36 Very long follow-up
11:36 Back up treatment very early on
12:41 End

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TT HealthWatch - Friday, February 16, 2024

This week's topics include allocating donor hearts, an online program for long Covid, electronic cigarettes for smoking cessation, and reversing anticoagulation in hemorrhagic strokes.

0:40 Who gets a donor heart?
1:41 Mechanical support system
2:42 Assess new guidelines
3:32 E-cigarettes in helping people stop smoking
4:32 Validated abstinence at 6 months
5:32 Doesn't stop nicotine use
6:32 Are deleterious effects
7:01 Reversing anticoagulation in hemorrhagic stroke
8:01 Almost 10,000 such strokes
9:01 Not as much of a barrier to reverse
9:20 Online program for long Covid
10:20 Health related quality of life outcome
11:20 Applied generally?
12:20 Related to deconditioning
13:06 End

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TT HealthWatch - Friday, February 9, 2024

This week's topics include a new treatment for NASH, human milk for preterm infants, psoriasis treatment, and managing gout with uric acid levels.

0:34 NASH treatment
1:34 Two dosages and placebo
2:32 Similar incidence of adverse events
3:32 Minor effects on heart or bone?
4:15 Psoriasis treatment
5:15 Decreased plaques by 75%
6:05 Human milk, preterm infants, neurodevelopment
7:05 Black infants 52%
8:07 Decreased necrotizing enterocolitis
9:14 Uric acid levels and gout flares
10:15 3600 patients with gout
11:15 Keep levels at five or below
12:15 End

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TT HealthWatch - Friday, February 2, 2024

This week's topics include a possible cause for long Covid, screening for language disorders and delays in kids, costs of healthcare when someone with cancer gets switched to a high deductible plan, and diabetes remission health impact.

0:33 Long Covid and the complement system
1:33 Top biomarkers identified
2:32 Which complement pathway involved?
3:35 Identify those at risk
3:50 Remission of type 2 diabetes and health outcomes
4:50 Reduced rate of CKD and CVD
5:50 1200 to 1800 kCal per day
6:50 Direct trial in UK
7:03 USPSTF screening for speech and language disorders
8:03 No studies evaluate screening
9:03 Different in different cultures
9:16 Out of pocket costs for patients with cancer and high deductible plans
10:17 Over 2700 in high deductible group
11:15 Sacrificed non-cancer and primary care
12:25 End

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TT HealthWatch - Friday, January 26, 2024

This week's topics include closing the women's health gap, how seniors use the health care system, cancer after weight loss, and PFAS guidelines for clinicians.

0:30 Cancer diagnosis after weight loss
1:30 Two times the frequency
2:33 PFAS guidance for clinicians
3:30 Half-life of eight or more years
4:31 Increased preeclampsia
5:31 Screen water supply
6:23 Understanding how older adults use health care system
7:23 Overdiagnosis, hypervigilance, indicated?
8:23 World Economic Forum on women's health gap
9:23 Avoid 24 million life-years lost
10:23 Ischemic heart disease, tuberculosis
11:21 Women pay more for health insurance
12:34 End

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TT HealthWatch - Friday, January 19, 2024

This week's topics include a look at congenital syphilis, a way of treating some people with congestive heart failure, palliative care in two different populations, and breast cancer outcomes over fifty years.

0:32 Long term outcomes in heart failure
1:32 Defibrillator with pacing
2:30 Like putting in a pacemaker
2:50 Congenital syphilis
3:50 Consequences for neonate dire
4:50 Time sensitive treatment
5:50 Almost 4000 cases in 2022
6:30 Breast cancer mortality in last fifty years
7:30 Hormone negative screening very important
8:15 Palliative care in two populations
9:15 Nurse intervention with social worker effective
10:15 Needs to be resourced
11:15 Resistance by some clinicians
12:30 End

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TT HealthWatch - Friday, January 12, 2024

This week's topics include a proteomic approach to cancer screening, vegetarian diet and COVID-19 risk, performance of dialysis centers, and medical errors in hospitalized patients.

0:40 Incentivizing dialysis centers
1:40 Over 1000 dialysis centers
2:40 How to adjust for neighborhood?
3:41 Comprehensive approach needed
4:00 Vegetarian diet and COVID-19 risk
5:03 Importance of diet and disease
6:00 Immunity and foods
6:12 Diagnostic errors in hospitalized patients
7:12 Problems assessing the patient
8:18 Novel proteomics-based cancer screening
9:18 10 proteins with high accuracy
10:18 Different in men and women
11:18 Most useful biomarkers the low concentration ones
12:05 End

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TT HealthWatch - Friday, January 5, 2024

This week's topics include a new medication for atrial fibrillation, a comprehensive approach to prepregnancy through early childhood, opening the blood-brain barrier for an Alzhiemer's antibody treatment, and management of TMD.

0:47 Temporomandibular disorders and management
1:47 10cm visual analog scale
2:47 In subtypes expect some variation
3:36 Which relieves pain and which improves function
4:27 Opening the blood brain barrier and using an antibody for Alzheimer's
5:27 Applied on one side of brain
6:27 Does it reverse or halt dementia?
7:00 A multidomain intervention in preconception through early childhood
8:00 Was helpful in childhood outcomes
9:00 Don't know which factor was most effective
10:00 How to assess factors separately
10:15 IV drug for early atrial fibrillation
11:15 Phase two study
12:43 End

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